Exercise and Neuroprotection and Neurorestoration in Rodent Models of PD:
Neuroplasticity is a process by which the brain encodes experiences and learns new behaviors and is defined as the modification of existing neural networks by adding or modifying synapses. Evidence is accumulating that both goal directed and aerobic exercise may strengthen and improve motor circuitry through mechanisms that include but are not limited to alterations and glutamate neurotransmission, as well as structural modifications of synapses. In addition, exercise may promote neuroprotection of substantia nigra neurons and their existing connections. Finally, exercise-induced alterations in blood flow and general brain health may promote conditions for neuroplasticity important for facilitating motor skill learning, including cognitive and automatic motor control and overall behavioral performance. While more studies are clearly needed, taken together these findings are supportive of a disease modifying effect of exercise.
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